Penk-IRES-Cre

Nomenclature

C57BL/6Smoc-Penkem1(IRES2-iCre)Smoc

Cat. NO.

NM-KI-200088

Strain State

Repository Live

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Gene Summary

Gene Symbol
Penk

Synonyms

ENK; PPA; Penk1; AI326464

NCBI ID

18619

MGI ID

104629

Ensembl ID

ENSMUSG00000045573

Pubmed

Penk

Human Ortholog

PENK

Model Description

A IRES2-iCre expression cassette was knocked into the Penk gene stop codon site.
Research Application：Penk gene encodes prodynorphin. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. The gene product is involved in regulating synaptic plasticity, a crucial neurochemical mechanism underlying learning and memory.

Validation Data

NM-KI-200088 Penk-IRES-Cre-1.png

Fig. 1 Cre-mediated recombination in the brain of PenkCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the brain of PenkCre/+; Rosa26tdTomato/+ mouse.

NM-KI-200088 Penk-IRES-Cre-2.png

Fig. 2 Detection of tdTomato(red) in various tissues of  PenkCre/+; Rosa26tdTomato/+ mice. Tdtomato is expressed throughout the brain. And cre-mediated recombination can be detected in some cells of the pituitary gland, kidney, intetstine, colon, retina, brown fat, testis, epididymis, salivary gland, stomach, thymus, lung, heart, liver and skin. (For more detailed information please contact our technical advisor.)

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