Zap70-W163C(Balb/c)

Nomenclature

BALB/cAnSmoc-Zap70em(W163C)Smoc

Cat. NO.

NM-KI-210366

Strain State

Repository Live

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Gene Summary

Gene Symbol
Zap70

Synonyms

Srk; mur; mrtle; ZAP-70

NCBI ID

22637

MGI ID

99613

Ensembl ID

ENSMUSG00000026117

Pubmed

Zap70

Human Ortholog

ZAP70

Model Description

These mice carry a W163C mutation of Zap70 gene.
Research Application：Rheumatoid arthritis model， Ankylosing spondylit，SKG mouse arthritis modelis model

Disease Connection

Rheumatoid Arthritis

Phenotype(s)

MGI:3698734

Reference(s)

Sakaguchi N, Takahashi T, Hata H, Nomura T, Tagami T, Yamazaki S, Sakihama T, Matsutani T, Negishi I, Nakatsuru S, Sakaguchi S, Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature. 2003 Nov 27;426(6965):454-60

Validation Data

image.pngFig1. Elicitation of chronic arthritis by administration of Mannan. 

Signs of arthritis were assessed by a visual score where 0=no joint swelling, 1=mild to moderate swelling, 2=substantial swelling of the wrist or ankle joint, and 3=severe swelling of the wrist or ankle joint.

Publications

A novel Anti-ROS osteoblast-specific delivery system for ankylosing spondylitis treatment via suppression of both inflammation and pathological new bone formation
References：Journal of Nanobiotechnology

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