Cat. NO.


Strain State

Repository Live

Export PDF

Gene Summary

Gene Symbol

Model Description

The endogenous mouse Ccr8 gene was replaced by human CCR8 gene. While hCCR8(Stock No.NM-HU-190053) mice function similarly to hCCR8(2) mice,for more detailed information please contact our technical advisor.
Research Application:Immunotherapy,drug screening

Validation Data


Fig1. Expression characterization of CCR8 humanized mouse. 

(A) Human CCR8 expression on activated splenic CD4+, CD8+ and Treg cells upon anti-mCD3/mCD28 stimulation in hCCR8 mice; (B) Statistics of T cell populations in hCCR8 mice.


Fig2. The anti-hCCR8 therapeutic antibody shows potent antitumor efficacy in hCCR8 mice. 

(A) and (B) in vivo antitumor response of anti-hCCR8 in hCCR8 mice bearing MC38 tumor.


Fig3. In vivo antitumor responses of anti-hCCR8 alone or in combination with anti-PD-1 in hCCR8 knockin mice engrafted with MC38 tumor. 

(A) Mean tumor growth curves upon treatment; (B) Individual tumor growth curves upon treatment.


Fig4. In vivo efficacy study in CCR8 humanized mice grafted with MC38 tumor model. JTX-1811 can inhibit the growth of MC38 xenografts (A) without significant effect on the body weight of CCR8 humanized mice (B).(provided by partner)

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more