hIL10

Nomenclature

C57BL/6Smoc-Il10tm4(hIL10)/Smoc

Cat. NO.

NM-HU-2000063

Strain State

Embryo cryopreservation

Export PDF

Gene Summary

Gene Symbol
Il10

Model Description

The endogenous mouse Il10 gene was replaced by human IL10 gene.
Research Application:Cytokine humanization model;drug screening

Validation Data

image.png

Fig1. Detection of IL10 expression in bladder by RT-PCR. 

Wild type: only one band at 362 bp with primers F1/R1(mIl10);

Homozygous: only one band at 196 bp with primers F2/R2(hIL10).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig2. Detection of human and mouse IL10 expression in serum by ELISA (n=2). 

Abbr. HO, homozygous; WT, wild type.

Note. hIL10 and C57BL/6 mice were i.p. injected with LPS for 2h.




You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more