hTREM2

Nomenclature

C57BL/6Smoc-Trem2em4(hTRem2)/Smoc

Cat. NO.

NM-HU-2000083

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Trem2

Model Description

The endogenous mouse Trem2 gene was replaced by human TREM2 gene.
Research Application:Alzheimer's disease research;drug screening

Validation Data

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Fig1. Detection of TREM2 expression in brain by RT-PCR. Wild type: only one band at 344 bp with primers F1/R1(mTrem2);Homoygous: only one band at 308 bp with primers F2/R2(hTREM2); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Fig2. hTREM2 Expression in Tumor-infiltrating Macrophages in hTREM2 Mice Bearing MC38 Syngenic Tumors. (Anti-hTREM2 antibody provided by the third party)

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Fig3. hTREM2 Expression in Tumor-infiltrating Macrophages in hTREM2 Mice Bearing MC38 Syngenic Tumors. (The commercial Anti-hTREM2 antibody has cross reactivity with mouse TREM2)


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