hVEGFR2

Nomenclature

C57BL/6Smoc-Kdrtm2(hKDR) Smoc

Cat. NO.

NM-HU-00098

Strain State

Repository Live

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Gene Summary

Gene Symbol
KDR

Model Description

The endogenous mouse Kdr gene was replaced by human KDR gene .
Research Application:Immunotherapy,cancer research,drug screening

Validation Data

验证数据-KDR-HU-图片1.png

Figure 1. Expression of mouse KDR and human KDR in C57BL/6 wild type mice and KDR-HU homozygous mice.

验证数据-KDR-HU-图片2.png

Figure 2:In vivo validation of anti-tumor efficacy in a B16F1 tumor-bearing model of humanized KDR mice. The results showed: The drugs targeting human KDR were associated with a very significant anti-tumor, demonstrating that the humanized KDR mice are a good in vivo model for validating the efficacy of drugs targeting human KDR.


验证数据-KDR-HU-图片3.png

Figure 3:In vivo validation of anti-tumor efficacy in a MC38 tumor-bearing model of humanized KDR mice. The results showed: The drugs targeting human KDR were associated with a very significant anti-tumor.



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