hTNFa-Tg
Nomenclature
C57BL/6Smoc-Tgtn(hTNFa promoter-hTNFa-pA)Smoc
Cat. NO.
NM-TG-200004
Strain State
Repository Live
Gene Summary
Gene Symbol
Model Description
Validation Data
Fig.1 Detection of hTNFα expression in serum by ELISA (male, 8-12wks, n=2).
Abbr. WT, wild type.
Note. hTNFα-Tg and C57BL/6 mice were i.p. injected with LPS for 2h.
Fig.2 Detection of mTnfα expression in serum by ELISA (male, 8-12wks, n=2).
Abbr. WT, wild type.
Note. hTNFα-Tg and C57BL/6 mice were i.p. injected with LPS.
Fig.3 Body Weight of hTNFα-Tg (male, 5-6wks, n=10).
Fig4. Clinical score of joint swelling in hTNFa-Tg mice and representative diagram of hind limb joints of mice in each group on day 94.
Fig.5 Clinical score of joint swelling hTNFα mice (male, 5-6wks, n=10).
Signs of arthritis were assessed by a visual score where 0 = Normal paw, 1 = one toe inflamed or swollen, 2 = more than one toe, but not entire paw, or mild swelling of the entire paw, 3 = entire paw inflamed and swollen, and 4 = very inflamed and swollen paw or ankylosed paw.
Fig.6 Micro-CT image of hTNFα-Tg mice. hTNFα-Tg mice have significant articular bone flow type.
Fig.7 Micro-CT image of hTNFα-Tg mice. The tibia of hTNFα-Tg mice shows no significant difference.
Fig.8 Score of hTNFα-Tgmice (A) and H&E pathology(B). (male)
Compared with the WT C57BL/6, the mixed inflammatory cell infiltration in hTNFα-Tg mice is significantly increased, with obvious proliferation of synovial joints, formation of pannus, fibroblast tissue production, and cartilage erosion.
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