hAPOC3

Nomenclature

C57BL/6Smoc-Apoc3em1(hAPOC3)Smoc

Cat. NO.

NM-HU-225050

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Apoc3

Synonyms

apo-CIII; apoC-III

NCBI ID

11814

MGI ID

88055

Ensembl ID

ENSMUSG00000032081

Pubmed

Apoc3

Human Ortholog

APOC3

Model Description

The endogenous mouse Apoc3 gene was replaced by human APOC3 gene.

Validation Data

image.png

Fig1. Detection of APOC3 expression in liver by RT-PCR. 

Wild type: only one band at 196 bp with primers F1/R1(mApoc3); Homozygous: only one band at 219 bp with primers F2/R2(hAPOC3). Abbr. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

image.png

Fig2. Detection of species-specific APOC3 expression in serum by ELISA. 

Abbr. HO, homozygous; HE, heterozygous; WT, wild type.

image.png

Fig3. Monitoring of blood lipids levels in hAPOC3 mice (n=3 female and 3 male). 

Abbr. Hom, homozygous; WT, wild type.

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