Ppargc1a-KO

Nomenclature

C57BL/6Smoc-Ppargc1aemSmoc

Cat. NO.

NM-KO-210177

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Ppargc1a

Synonyms

Pgc1，PGC-1，Pgco1，Gm11133，Ppargc1，Pgc-1alpha，A830037N07Rik，PPARGC-1-alpha

NCBI ID

19017

MGI ID

1342774

Ensembl ID

ENSMUSG00000029167

Pubmed

Ppargc1a

Human Ortholog

PPARGC1A

Model Description

exon 3-5 of Ppargc1a gene was deleted to generate Ppargc1a knockout mice.

Disease Connection

Age Related Macular Degeneration

Phenotype(s)

MGI:6389045

Reference(s)

Zhang M, Chu Y, Mowery J, Konkel B, Galli S, Theos AC, Golestaneh N, Pgc-1alpha repression and high-fat diet induce age-related macular degeneration-like phenotypes in mice. Dis Model Mech. 2018 Aug 16;11(9):dmm032698

Parkinson's Disease

Phenotype(s)

MGI:6489606

Reference(s)

Sun Z, Ma X, Yang H, Chen S, He S, Sun R, Lu H, Zhang J, Characterization of Age-dependent Behavior Deficits in the PGC-1alpha Knockout Mouse, in Relevance to the Parkinson's Disease Model. Neuroscience. 2020 Aug 1;440:39-47

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