Plp1-Flox

Nomenclature

C57BL/6Smoc-Plp1em1(flox)Smoc

Cat. NO.

NM-CKO-200072

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Plp1

Synonyms

jp， Plp， msd， rsh， DM20， jimpy

NCBI ID

18823

MGI ID

97623

Ensembl ID

ENSMUSG00000031425

Pubmed

Plp1

Human Ortholog

PLP1

Model Description

These mice carry loxP sites flanking exon 3 of Plp1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Plp1 gene.
Research Application：The study of glial cell differentiation and the susceptibility pathway of sudden infant death syndrome (SIDS)

Disease Connection

Hereditary Spastic Paraplegia 2

Phenotype(s)

MGI:6160757
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Cnp-Cre mice.

Reference(s)

Luders KA, Patzig J, Simons M, Nave KA, Werner HB, Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2. Glia. 2017 Nov;65(11):1762-1776

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