Smad4-Flox

Nomenclature

C57BL/6Smoc-Smad4tm1(flox)Smoc

Cat. NO.

NM-CKO-18011

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Smad4

Synonyms

DPC4; Madh4; AW743858; D18Wsu70e

NCBI ID

17128

MGI ID

894293

Ensembl ID

ENSMUSG00000024515

Pubmed

Smad4

Human Ortholog

SMAD4

Model Description

These mice carry loxP sites flanking exon3-4 of Smad4 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Smad4 gene.

Disease Connection

Osteogenesis Imperfecta

Phenotype(s)

MGI:5604139
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Sp7-tTA,tetO-EGFP/cre mice.

Reference(s)

Salazar VS, Zarkadis N, Huang L, Norris J, Grimston SK, Mbalaviele G, Civitelli R, Embryonic ablation of osteoblast Smad4 interrupts matrix synthesis in response to canonical Wnt signaling and causes an osteogenesis-imperfecta-like phenotype. J Cell Sci. 2013 Nov 1;126(Pt 21):4974-84

Squamous Cell Carcinoma

Phenotype(s)

MGI:5556259
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Kras-LSL-G12D(NM-KI-190003) and Krt1-15-cre mice.

Reference(s)

White RA, Neiman JM, Reddi A, Han G, Birlea S, Mitra D, Dionne L, Fernandez P, Murao K, Bian L, Keysar SB, Goldstein NB, Song N, Bornstein S, Han Z, Lu X, Wisell J, Li F, Song J, Lu SL, Jimeno A, Roop DR, Wang XJ, Epithelial stem cell mutations that promote squamous cell carcinoma metastasis. J Clin Invest. 2013 Oct 1;123(10):4390-404

Stomach Cancer

Phenotype(s)

MGI:5634400
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Cdh1-Flox(NM-CKO-18016)，P53-Flox(2)(NM-CKO-190067) and Pdx1-cre mice.

Reference(s)

Park JW, Jang SH, Park DM, Lim NJ, Deng C, Kim DY, Green JE, Kim HK, Cooperativity of E-cadherin and Smad4 Loss to Promote Diffuse-Type Gastric Adenocarcinoma and Metastasis. Mol Cancer Res. 2014 Aug;12(8):1088-99

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