Xpc-KO

Nomenclature

C57BL/6Smoc-Xpcem1Smoc

Cat. NO.

NM-KO-200589

Strain State

Sperm cryopreservation

Export PDF

Gene Summary

Gene Symbol
Xpc

Synonyms

NCBI ID

22591

MGI ID

103557

Ensembl ID

ENSMUSG00000030094

Pubmed

Xpc

Human Ortholog

XPC

Model Description

Exon 3 of Xpc gene was deleted to generate Xpc knockout mice.
Research Application：Cancer research

Disease Connection

Lung Cancer

Phenotype(s)

MGI:3719353
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Gadd45a-KO(NM-KO-200590) mice.

Reference(s)

Hollander MC, Philburn RT, Patterson AD, Velasco-Miguel S, Friedberg EC, Linnoila RI, Fornace AJ Jr, Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13200-5

lung cancer

Phenotype(s)

MGI:3719290

Reference(s)

Hollander MC, Philburn RT, Patterson AD, Velasco-Miguel S, Friedberg EC, Linnoila RI, Fornace AJ Jr, Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13200-5

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more