Wnt1-Dre

Nomenclature

C57BL/6Smoc-Wnt1em1(Dre-Wpre-polyA)Smoc

Cat. NO.

NM-KI-200176

Strain State

Sperm cryopreservation

Export PDF

Gene Summary

Gene Symbol
Wnt1

Model Description

A Dre-Wpre-polyA expression cassette was knocked into the Wnt1 gene start codon site. Wnt1 gene is involved in stem cell poliferation in multiple systems, including the hematopoietic system and the embryonic nervous system. This strain may be useful for studying central nervous system development. When crossed with a strain carrying a gene flanked by rox sites, the flanked gene will be removed in cells expressing dre.
Research Application:Dre recombinase tool; Neurosciences

Validation Data

image.png

Fig. 1 Dre-mediated recombination in the brain of Wnt1Dre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the cerebellar purkinje cells and epithalamus cells of Wnt1Dre/+; Rosa26tdTomato/+ mouse.

image.png

Fig. 2 Dre-mediated recombination in the brain of Wnt1Dre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in some cells of the ventricle of Wnt1Dre/+; Rosa26tdTomato/+ mouse.

image.png

Fig. 3 Detection of tdTomato(red) in various tissues of Wnt1Dre/+; Rosa26tdTomato/+ mice. Dre mediated recombination can be detected in some cells of the lung, salivary gland, brain, eyes, stomach, thymus, colon, intestinal crypt, ovary, liver and pancreas. Tdtomato expression can not be observed in the brown fat, heart, kidney, spleen or muscle. (For more detailed information please contact our technical advisor.)



You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more