BALB/c Nude

Nomenclature

BALB/cAnSmoc-Foxn1nu/Smoc

Cat. NO.

SM-014

Strain State

Repository Live

Export PDF

Gene Summary

Gene Symbol
Foxn1

Model Description

This strain carries a Foxn1nu mutation on the BALB/c background which will lead to T cell deletion. At the same time, the response to thymus-dependent antigens is limited, resulting in impaired B cell function while NK cells, macrophages, and antigen-presenting cells function normally. The complement activity is normal as well. Hair dysplasia causes aberrant hair growth in which the majority of the hair cannot protrude from the surface, resulting in a naked mouse phenotype.



Validation Data

image.png

Fig1. Body weight growth curve of BALB/c Nude (n=30)

image.png

Fig2. Complete deletion of T, B cells of BALB/c Nude. 

image.png

Fig3. Subcutaneous xenograft tumor growth in BALB/c Nude. 

image.png

Fig4. Blood routine tests in BALB/c Nude.

image.png

Fig5. Blood biochemistry in BALB/c Nude.

Table 1. BALB/c Nude xenograft cell lines

image.png


You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more