MHCII/B2m-KO(NMG)
Nomenclature
NOD.Cg-PrkdcscidIl2rgem1SmocH2-Ab1em1SmocH2-Aaem1SmocH2-Eb1em1SmocH2-Eb2em1SmocH2-Ea-psem1SmocB2mem1Smoc
Cat. NO.
NM-NSG-014
Strain State
Repository Live
Gene Summary
Gene Symbol
B2M
Gene Symbol
MHCII(H2-Ab1; H2-Aa; H2-Eb1; H2-Eb2; H2-Ea)
Model Description
All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.Also, B2m gene was knocked out. These MHC class I and II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins and B2m of class I.
Validation Data
Fig1. Detection of MHCII and B2m expression in spleen in MHCII/B2M-dKO (M-NSG) mice by RT-PCR.
Fig2. Expression characterization of mouse MHC I and MHC II in MHCII/B2M-dKO (M-NSG) mice.
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