Lrp5-KO

Nomenclature

C57BL/6Smoc-Lrp5em1Smoc

Cat. NO.

NM-KO-190683

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Lrp5

Synonyms

HBM， LR3， LRP7， OPPG， BMND1， mKIAA4142

NCBI ID

16973

MGI ID

1278315

Ensembl ID

ENSMUSG00000024913

Pubmed

Lrp5

Human Ortholog

LRP5

Model Description

Exon 2 of Lrp5 gene was deleted to generate Lrp5 knockout mice.
Research Application：Negative regulator of the Wnt-beta-catenin-Tcf signaling pathway.

Disease Connection

Exudative Vitreoretinopathy

Phenotype(s)

MGI:4946082

Reference(s)

Wang Z, Liu CH, Sun Y, Gong Y, Favazza TL, Morss PC, Saba NJ, Fredrick TW, He X, Akula JD, Chen J, Pharmacologic Activation of Wnt Signaling by Lithium Normalizes Retinal Vasculature in a Murine Model of Familial Exudative Vitreoretinopathy. Am J Pathol. 2016 Oct;186(10):2588-600

Osteoporosis-Pseudoglioma Syndrome

Phenotype(s)

MGI:3664613

Reference(s)

Kato M, Patel MS, Levasseur R, Lobov I, Chang BH, Glass DA 2nd, Hartmann C, Li L, Hwang TH, Brayton CF, Lang RA, Karsenty G, Chan L, Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol. 2002 Apr 15;157(2):303-14

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