Itga2b-KO

Nomenclature

C57BL/6Smoc-Itga2bem1Smoc

Cat. NO.

NM-KO-200719

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Itga2b

Synonyms

CD41， CD41B， GpIIb， AI172977， alphaIIb

NCBI ID

16399

MGI ID

96601

Ensembl ID

ENSMUSG00000034664

Pubmed

Itga2b

Model Description

Exon 4 of Itga2b gene was deleted to generate Itga2b knockout mice.

Disease Connection

Platelet-Type Bleeding Disorder 16

Phenotype(s)

MGI:2677136

Reference(s)

Tronik-Le Roux D, Roullot V, Poujol C, Kortulewski T, Nurden P, Marguerie G, Thrombasthenic mice generated by replacement of the integrin alpha(IIb) gene: demonstration that transcriptional activation of this megakaryocytic locus precedes lineage commitment. Blood. 2000 Aug 15;96(4):1399-408

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