Stk11-Frox

Nomenclature

C57BL/6Smoc-Stk11em1(frox)Smoc

Cat. NO.

NM-CKO-200251

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Stk11

Synonyms

Lkb1; Par-4; R75140; AA408040

NCBI ID

20869

MGI ID

1341870

Ensembl ID

ENSMUSG00000003068

Pubmed

Stk11

Human Ortholog

STK11

Model Description

These mice carry rox sites flanking exon3-6 of Stk11 gene. When crossed with a Dre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Stk11 gene.

Disease Connection

Endometrial Cancer

Phenotype(s)

MGI:4438263
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Sprr2f-cre mice.

Reference(s)

Contreras CM, Akbay EA, Gallardo TD, Haynie JM, Sharma S, Tagao O, Bardeesy N, Takahashi M, Settleman J, Wong KK, Castrillon DH, Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy. Dis Model Mech. 2010 Mar-Apr;3(3-4):181-93

Urinary Bladder Cancer

Phenotype(s)

MGI:5789953
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pten-Flox(NM-CKO-18004) and Cyp1a1-cre/ERT mice.

Reference(s)

Shorning BY, Griffiths D, Clarke AR, Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder. PLoS One. 2011;6(1):e16209

Peutz-Jeghers Syndrome

Phenotype(s)

MGI:3814590
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pdx1-cre mice.

Reference(s)

Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, Dor Y, Bardeesy N, Depinho RA, Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol. 2008 Apr;28(7):2414-25

Peutz-Jeghers syndrome

Phenotype(s)

MGI:3814722
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with KRT14-cre mice.

Reference(s)

Gurumurthy S, Hezel AF, Berger JH, Bosenberg MW, Bardeesy N, LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis. Cancer Res. 2008 Jan 1;68(1):55-63

Skin Melanoma

Phenotype(s)

MGI:5752239
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Cdkn2a-Flox(2)(NM-CKO-200151)，Nras-Flox(NM-CKO-2100519) and Tyr-cre/ERT2 mice.

Reference(s)

Burd CE, Liu W, Huynh MV, Waqas MA, Gillahan JE, Clark KS, Fu K, Martin BL, Jeck WR, Souroullas GP, Darr DB, Zedek DC, Miley MJ, Baguley BC, Campbell SL, Sharpless NE, Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma. Cancer Discov. 2014 Dec;4(12):1418-29

Peutz-Jeghers Syndrome

Phenotype(s)

MGI:5440238
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Amhr2-Cre mice.

Reference(s)

Tanwar PS, Kaneko-Tarui T, Zhang L, Teixeira JM, Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis. Hum Mol Genet. 2012 Oct 15;21(20):4394-405

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