hTLR2

Nomenclature

C57BL/6Smoc-Tlr2em2(hTLR2)Smoc

Cat. NO.

NM-HU-190066

Strain State

Embryo cryopreservation

Export PDF

Gene Summary

Gene Symbol
Tlr2

Synonyms

Ly105

NCBI ID

24088

MGI ID

1346060

Ensembl ID

ENSMUSG00000027995

Pubmed

Tlr2

Human Ortholog

TLR2

Model Description

The endogenous mouse Tlr2 gene was replaced by human TLR2 gene.
Research Application：Immunotherapy,cancer research,drug screening

Validation Data

1.png

Fig1. Strain specific hTLR2 expression analysis in homozygous hTLR2 mice by flow cytometry. Macrophages of PBMC were collected from WT and homozygous hTLR2 mice, and analyzed by flow cytometry with species-specific anti-hTLR2 and anti-mTLR2 antibody.  hTLR2 was detectable in a subset of macrophages in homozygous hTLR2 mice, and the mTLR2 was not expressed.

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more