Vegfa-KO

Nomenclature

C57BL/6Smoc-Vegfaem1Smoc

Cat. NO.

NM-KO-190539

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Vegfa

Synonyms

Vpf， Vegf

NCBI ID

22339

MGI ID

103178

Ensembl ID

ENSMUSG00000023951

Pubmed

Vegfa

Human Ortholog

VEGFA

Model Description

Exon 1-6 of Vegfa gene was deleted to generate Vegfa knockout mice.
Research Application：Growth Factors，Diabetes.

Disease Connection

Amyotrophic Lateral Sclerosis Type 1

Phenotype(s)

MGI:3796444

Reference(s)

Oosthuyse B, Moons L, Storkebaum E, Beck H, Nuyens D, Brusselmans K, Van Dorpe J, Hellings P, Gorselink M, Heymans S, Theilmeier G, Dewerchin M, Laudenbach V, Vermylen P, Raat H, Acker T, Vleminckx V, Van Den Bosch L, Cashman N, Fujisawa H, Drost MR, Sciot R, Bruyninckx F, Hicklin DJ, Ince C, Gressens P, Lupu F, Plate KH, Robberecht W, Herbert JM, Collen D, Carmeliet P, Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet. 2001 Jun;28(2):131-8

Newborn Respiratory Distress Syndrome

Phenotype(s)

MGI:3047228

Reference(s)

Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, Plaisance S, Dor Y, Keshet E, Lupu F, Nemery B, Dewerchin M, Van Veldhoven P, Plate K, Moons L, Collen D, Carmeliet P, Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med. 2002 Jul;8(7):702-10

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